Key expertise
Lipids
In the pharmaceutical industry, lipids are core excipients in the development of drug delivery systems. Lipids can be used in most dosage forms as support vehicles, solubilizers, permeation enhancers, stabilizers, transfection agents and release rate modifiers.
Li
Lipids
Your global partner for the manufacturing of synthetic lipids
Such ingredients are particularly relevant for the development of optimized RNA / DNA delivery systems, and allow a better bioavailability of drugs or vectorized vaccines.
Our commitment is to support our customers in reaching the highest requirements in terms of ingredients performances, selectivity and quality. Our services allow to fine-tune the chemical structure, create opportunities for IP generation, and deliver the products at all stages of the product life cycle.
Seqens answers customers’ needs for Custom Lipids, which are typically used in drug delivery systems to improve the bioavailability of drugs :
- Lipid Nanoparticles for mRNA/siRNA/DNA
- Transfection Vectors for Gene Therapies
- Immunotherapies (CAR-T-Cells)
- Lipid prodrugs
- Liposome Vectorization for Oncology, Pain…
- Lipid-Polymer Hybrid Nanoparticles
- Cosmetic Lipids
2 expert R&D centers for drug delivery lipids
BOSTON’LAB: Small Molecules, Lipids & Polymers
- 1,000 m² lab-floor
- 5 kilo-labs
- 1 pilot plant
- 30 scientists with > 50% PHD
SEQENS’LAB: Small Molecules & Lipids
- 4 kilo-labs
- 2 cGMP pilot plants with 11 multipurpose reactors (total capacity of 12 m3)
- 110 scientists with > 50% PHD
Our custom lipids offer
With a recognized 10 years-experience in Custom Lipids development and manufacturing, Seqens has the ability to serve customers with:
- Neutral Lipids
- PEG-lipids
- Cationic/Ionizable lipids
- Phospholipids
- Cholesterol derivatives
- Intermediates
Seqens has a wide range of expertise in synthetic Lipid process development and scale-up, benefiting from existing assets:
1
CGMP CUSTOM LIPID CDMO
Capabilities in US and EU
Support preclinical & clinical studies
From grams to tens of kilograms
2
TOLLING CAPABILITIES
For commercial-scale cGMP Lipid synthesis
Up to multi-tons scale
3
CUSTOM LIPID INTERMEDIATES
Leveraging Seqens worldwide non-GMP Assets
Up to multi-tons scale
Our technologies’ offer for custom lipids development and manufacturing
Available at Lab scale, GMP kg-Lab scale and GMP commercial supply
Synthesis
- Non-GMP reactors for lipid intermediates
- GMP reactors for GMP lipids
Purification
- Flash Chromatography
- High Pressure Chromatography (under upgrade for GMP scale-up)
- Solvent evaporation
- Crystallization and drying
Analytics
- Best-in-class analytical tools (including Thin-layer Chromatography/MS)
- Stability studies
- Process safety studies